Relationship between Physical Activity and Plasma Fibrinogen Concentrations in Adults without Chronic Diseases

  • Published on Feb. 3, 2014

Objective: To analyze the relationship between regular physical activity, as assessed by accelerometer and 7-day physical activity recall (PAR), and plasma fibrinogen concentrations.

Methods: A cross-sectional study in a previously established cohort of healthy subjects was performed. This study analyzed 1284 subjects who were included in the EVIDENT study (mean age 55.0±13.6 years; 60.90% women). Fibrinogen concentrations were measured in blood plasma. Physical activity was assessed with a 7-day PAR (metabolic equivalents (METs)/hour/week) and GT3X ActiGraph accelerometer (counts/minute) for 7 days.

Results: Physical exercise, which was evaluated with both an accelerometer (Median: 237.28 counts/minute) and 7-day PAR (Median: 8 METs/hour/week). Physical activity was negatively correlated with plasma fibrinogen concentrations, which was evaluated by counts/min (r = −0.100; p<0.001) and METs/hour/week (r = −0.162; p<0.001). In a multiple linear regression analysis, fibrinogen concentrations of the subjects who performed more physical activity (third tertile of count/minute and METs/hour/week) respect to subjects who performed less (first tertile), maintained statistical significance after adjustments for age and others confounders (β = −0.03; p = 0.046 and β = −0.06; p<0.001, respectively).

Conclusions: Physical activity, as assessed by accelerometer and 7-day PAR, was negatively associated with plasma fibrinogen concentrations. This relation is maintained in subjects who performed more exercise even after adjusting for age and other confounders.

Figures: See full abstract for figures


  • Manuel A. Gomez-Marcos 1, 2
  • José I. Recio-Rodríguez 1
  • Maria C. Patino-Alonso 1, 3
  • Vicente Martinez-Vizcaino 4
  • Carme Martin-Borras 5
  • Aventina de-la-Cal-dela-Fuente 6
  • Ines Sauras-Llera 7
  • Alvaro Sanchez-Perez 8
  • Cristina Agudo-Conde 1
  • Luis García-Ortiz 1, 2
  • on behalf of the EVIDENT Study Investigators


Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service–SACYL, Salamanca, Spain
Department of Medicine, University of Salamanca, Salamanca, Spain
Stadistics Department, University of Salamanca, Salamanca, Spain
Social and Health Care Research Center, University of Castilla-La Mancha, Cuenca, Spain
DEA, Ciències de l'Educació i l'Esport (FPCEE) Universitat Ramon Llull, Barcelona, Spain
Casa of Barco Health Center, Castilla and León Health Service–SACYL,Valladolid, Spain
Torre Ramona Health Center, Aragón Health Service – Salud, Zaragoza, Spain
Primary Care Research Unit of Bizkaia, Basque Health Service-Osakidetza, Bilbao, Spain




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